The kynurenine pathway: a finger in every pie
J Savitz - Molecular psychiatry, 2020 - nature.com
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
[HTML][HTML] Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease
LM Chen, CH Bao, Y Wu, SH Liang, D Wang… - Journal of …, 2021 - Springer
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's
disease (CD), is a group of chronic bowel diseases that are characterized by abdominal …
disease (CD), is a group of chronic bowel diseases that are characterized by abdominal …
Kynurenine pathway in depression: A systematic review and meta-analysis
Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of
depression. However, the relationships between depression and each metabolite of the …
depression. However, the relationships between depression and each metabolite of the …
[HTML][HTML] Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
How to study anxiety and depression in rodent models of chronic pain?
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …
suffering from chronic pain. Over time, different tests and models have been developed in …
[HTML][HTML] Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations
A Muneer - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
[HTML][HTML] The role of the kynurenine signaling pathway in different chronic pain conditions and potential use of therapeutic agents
F Jovanovic, KD Candido, NN Knezevic - International journal of …, 2020 - mdpi.com
Tryptophan (TRP) is an essential, aromatic amino acid catabolized by indoleamine 2, 3-
dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) enzymes into kynurenine. The …
dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) enzymes into kynurenine. The …
Does kynurenic acid act on nicotinic receptors? An assessment of the evidence
TW Stone - Journal of neurochemistry, 2020 - Wiley Online Library
As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic
acid is of considerable biological and clinical importance as an endogenous antagonist of …
acid is of considerable biological and clinical importance as an endogenous antagonist of …
[HTML][HTML] Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics
S Fang, Z Wu, Y Guo, W Zhu, C Wan, N Yuan… - Frontiers in …, 2023 - frontiersin.org
Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells
in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural …
in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural …
[HTML][HTML] The kynurenine pathway and kynurenine 3-monooxygenase inhibitors
Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …