Model-informed drug discovery and development in pulmonary delivery: biopharmaceutical Pharmacometric Modeling for formulation evaluation of pulmonary …

T Sou, F Soukarieh, P Williams, MJ Stocks… - ACS …, 2020 - ACS Publications
For respiratory conditions, targeted drug delivery to the lungs could produce higher local
concentrations with reduced risk of adverse events compared to systemic administration …

Estimating clinically relevant measures of inhaled pharmaceutical aerosol performance with advanced in vitro and in silico methods

CA Ruzycki, WH Finlay, AR Martin - Organ Specific Drug Delivery …, 2022 - taylorfrancis.com
Recent advances in in vitro and in silico methods provide a number of opportunities for
better characterization of inhaled pharmaceutical aerosol performance in early drug …

Evolving In Vitro and In Silico Methods for Predicting Performance in Respiratory Drug Delivery Applications

CA Ruzycki - 2022 - era.library.ualberta.ca
The overarching theme of this work is the investigation and development of in vitro and in
silico methods used to characterize inhaled pharmaceutical aerosols. The ultimate aim is to …

Conor A. Ruzycki, Warren H. Finlay

AR Martin - Organ Specific Drug Delivery and Targeting to the …, 2022 - books.google.com
1.2. 1 Airway Geometry 1.2. 1.1 Realistic and semi-realistic extrathoracic geometries 1.2. 1.2
Idealized extrathoracic geometries 1.2. 1.3 In vitro measures of thoracic deposition 1.2. 2 …

[PDF][PDF] Inhaled rifampicin powder formulations and their in vivo studies for clinical application in tuberculosis treatment

P Khadka - 2021 - ourarchive.otago.ac.nz
Background Tuberculosis (TB), a global health problem caused by Mycobacterium
tuberculosis, mainly affects the lungs and spreads to other organs. Rifampicin is a potent …

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary …

F Soukarieh, P Williams, MJ Stocks - ACS Omega - nottingham-repository.worktribe.com
For respiratory conditions, targeted drug delivery to the lungs could produce higher local
concentrations with reduced risk of adverse events compared to systemic administration …