The skeletal system is responsible for weight-bearing, organ protection, and movement.
Bone diseases caused by trauma, infection, and aging can seriously affect a patient's quality …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

The inappropriate regenerated fibrous cartilage and subchondral bone of the injured
chondral defect ultimately cause degeneration of the regenerated cartilage, which …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage
polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …

Osteoarthritis not only results in cartilage lesion, but also is accompanied with subchondral
bone damage caused by the inflammatory response. It is of great significance to treat …

Osteoarthritis (OA) is the most common type of arthritis with no effective therapy.
Subchondral bone and overlying articular cartilage are closely associated and function as …

The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …