Background Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated
with disability and premature death. Up-to-date estimates of the burden of rheumatoid …

The Global status report on road safety 2018 launched by WHO in December 2018
highlights that the number of annual road traffic deaths has reached 1.35 million. Road traffic …

Background Rigorous analysis of levels and trends in exposure to leading risk factors and
quantification of their effect on human health are important to identify where public health is …

Although overall donation and transplantation activity is higher in Europe than on other
continents, differences between European countries in almost every aspect of …

Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to
three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as …

Background ADVANCE compared the efficacy and safety of two antiretroviral first-line
combinations (dolutegravir combined with emtricitabine and either tenofovir disoproxil …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Background Inclisiran is a double-stranded small interfering RNA that suppresses proprotein
convertase subtilisin–kexin type 9 (PCSK9) translation in the liver, leading to sustained …

Introduction: Obesity constitutes a major public health problem in Europe, but how the
obesity epidemic in European countries will evolve remains unknown. Most previous obesity …

Background Worldwide, both the incidence and death rates of pancreatic cancer are
increasing. Evaluation of pancreatic cancer burden and its global, regional, and national …