HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

HLA-G: too much or too little? Role in cancer and autoimmune disease

JM Martín-Villa, C Vaquero-Yuste… - Frontiers in …, 2022 - frontiersin.org
HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was
initially described at the maternal-fetal interface, and it was later found that this molecule …

HLA Class Ib-receptor interactions during embryo implantation and early pregnancy

LL Nilsson, TVF Hviid - Human Reproduction Update, 2022 - academic.oup.com
BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

The molecular and functional characteristics of HLA-G and the interaction with its receptors: where to intervene for cancer immunotherapy?

JVD Attia, CE Dessens, R van de Water… - International journal of …, 2020 - mdpi.com
Human leukocyte antigen G (HLA-G) mediates maternal-fetal immune tolerance. It is also
considered an immune checkpoint in cancer since it may mediate immune evasion and thus …

HLA-G genotype/expression/disease association studies: success, hurdles, and perspectives

G Amodio, S Gregori - Frontiers in Immunology, 2020 - frontiersin.org
The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological
condition, HLA-G surface expression is restricted to the maternal–fetal interface and to …

Role of HLA-G in viral infections

S Jasinski-Bergner, D Schmiedel… - Frontiers in …, 2022 - frontiersin.org
The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has
distinct features to classical HLA-A,-B,-C antigens, such as a low polymorphism, different …

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia

S Wedenoja, M Yoshihara, H Teder, H Sariola… - …, 2020 - thelancet.com
Background Fetal immune tolerance is crucial for pregnancy success. We studied the link
between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal …

A review of the main genetic factors influencing the course of COVID-19 in Sardinia: the role of human leukocyte antigen-G

S Mocci, R Littera, L Chessa, M Campagna… - Frontiers in …, 2023 - frontiersin.org
Introduction A large number of risk and protective factors have been identified during the
SARS-CoV-2 pandemic which may influence the outcome of COVID-19. Among these …

Roles of HLA-G/KIR2DL4 in breast cancer immune microenvironment

G Zheng, L Jia, AG Yang - Frontiers in Immunology, 2022 - frontiersin.org
Human leukocyte antigen (HLA)-G is a nonclassical MHC Class I molecule, which was
initially reported as a mediator of immune tolerance when expressed in extravillous …