Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Neurosteroids are key endogenous molecules in the brain that affect many neural functions.
We describe here recent advances in US National Institutes of Health (NIH)-sponsored and …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …

The mammalian target of rapamycin (mTOR) pathway is an essential cellular signaling
pathway involved in a number of important physiological functions, including cell growth …

We postulate that “system epilepsies”(SystE) are due to an enduring propensity to generate
seizures of functionally characterized brain systems. Data supporting this hypothesis—that …

The mammalian target of rapamycin (mTOR) signaling pathway regulates cell growth,
differentiation, proliferation, and metabolism. Loss‐of‐function mutations in upstream …

Epilepsy, a common neurological disorder and cause of significant morbidity and mortality,
places an enormous burden on the individual and society. Presently, most drugs for epilepsy …

Despite a large number of available medical options, many individuals with epilepsy are
refractory to existing therapies that mainly target neurotransmitter or ion channel activity. A …

Epileptic encephalopathies are a group of diseases in which epileptic activity itself
contributes to severe cognitive and behavioral impairments above and beyond what might …