Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis
AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …
Chemotherapy of leishmaniasis: present challenges
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …
of our time, affecting millions of people worldwide. The treatment of these serious diseases …
Extending the nested model for user-centric XAI: A design study on GNN-based drug repurposing
Whether AI explanations can help users achieve specific tasks efficiently (ie, usable
explanations) is significantly influenced by their visual presentation. While many techniques …
explanations) is significantly influenced by their visual presentation. While many techniques …
Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art
RL Charlton, B Rossi-Bergmann, PW Denny, PG Steel - Parasitology, 2018 - cambridge.org
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites
of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs …
of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs …
Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …
Genetic Analysis of Leishmania donovani Tropism Using a Naturally Attenuated Cutaneous Strain
WW Zhang, G Ramasamy, LI McCall, A Haydock… - PLoS …, 2014 - journals.plos.org
A central question in Leishmania research is why most species cause cutaneous infections
but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and …
but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and …
Leishmaniasis treatment: update of possibilities for drug repurposing
VV Andrade Neto, EF Cunha Junior, VS Faioes… - 2018 - arca.fiocruz.br
The leishmaniases represent a public health problem in under-developed countries and are
considered a neglected disease by the World Health Organization (WHO). They are cuased …
considered a neglected disease by the World Health Organization (WHO). They are cuased …
Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
Host-directed drug therapies for neglected tropical diseases caused by protozoan parasites
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for
significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs …
significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …