Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Chemotherapy of leishmaniasis: present challenges

SRB Uliana, CT Trinconi, AC Coelho - Parasitology, 2018 - cambridge.org
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

Extending the nested model for user-centric XAI: A design study on GNN-based drug repurposing

Q Wang, K Huang, P Chandak, M Zitnik… - … on Visualization and …, 2022 - ieeexplore.ieee.org
Whether AI explanations can help users achieve specific tasks efficiently (ie, usable
explanations) is significantly influenced by their visual presentation. While many techniques …

Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

RL Charlton, B Rossi-Bergmann, PW Denny, PG Steel - Parasitology, 2018 - cambridge.org
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites
of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs …

Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis

M Njoroge, NM Njuguna, P Mutai… - Chemical …, 2014 - ACS Publications
Neglected tropical diseases (NTDs) refer to a group of infectious diseases, which though
treatable and/or preventable, remain a leading cause of morbidity and mortality among the …

Genetic Analysis of Leishmania donovani Tropism Using a Naturally Attenuated Cutaneous Strain

WW Zhang, G Ramasamy, LI McCall, A Haydock… - PLoS …, 2014 - journals.plos.org
A central question in Leishmania research is why most species cause cutaneous infections
but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and …

Leishmaniasis treatment: update of possibilities for drug repurposing

VV Andrade Neto, EF Cunha Junior, VS Faioes… - 2018 - arca.fiocruz.br
The leishmaniases represent a public health problem in under-developed countries and are
considered a neglected disease by the World Health Organization (WHO). They are cuased …

Synthetic product-based approach toward potential antileishmanial drug development

R Pal, G Teli, MJ Akhtar, GSP Matada - European Journal of Medicinal …, 2023 - Elsevier
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

Host-directed drug therapies for neglected tropical diseases caused by protozoan parasites

S Varikuti, BK Jha, G Volpedo, NM Ryan… - Frontiers in …, 2018 - frontiersin.org
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for
significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs …

Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease

CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …