The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Resistance against nearly all antibiotics used clinically have been documented in bacteria.
There is an ever-increasing danger caused by multidrug-resistant Gram-negative bacteria in …

β-lactam antibiotics are among the most important and widely used antimicrobials worldwide
and are comprised of a large family of compounds, obtained by chemical modifications of …

The clinical management of prosthetic joint infections and other persistent bacterial
infections represents a major unmet medical need. The rifamycins are one of the most potent …

In order to obtain antimicrobial compounds with improved properties, new conjugates
comprising two different biologically active agents within a single chimeric molecule based …

In the current work, in continuation of our recent research, we synthesized and studied new
chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) …

Introduction: There is a growing need for new antibacterial agents, but success in
development of antibiotics in recent years has been limited. This has led researchers to …

This review is devoted to methods for the synthesis of 3, 4-disubstituted maleimides–
compounds that often show pronounced biological activity. We offer classification of …

The review summarizes recent advances in the synthesis of new derivatives of polyene
macrolide antibiotics by chemical modification and genetic engineering methods, results of …