In this study a general description of the use of solid support membranes as the device for
DNA delivery mediated by PAMAM dendrimers is presented. In contrast to the other DNA …

Experimental studies of viral gene delivery generally support the principle that virus-
mediated gene transfer is indeed possible. However, the field of gene therapy has not yet …

A major role of the early gene 1A and 1B products (E1A and E1B) in adenovirus infection is
to create a cellular environment appropriate for viral DNA replication. This is, in part …

Macrophages are normal targets for Salmonella during natural infections, and it has been
demonstrated that attenuated bacteria can deliver nucleic acid vaccine constructs …

荧光定量PCR (Fluorescence Quantitive Polymerase Chin Reaction FQ-PCR) 技术是在90
年代末期发展起来的一项全新技术. 经过几年的实践及临床应用, 已获得了较为稳定的检测效果 …

Gene therapy is a potential new strategy for the treatment of cardiovascular disease. The
most efficacious method of gene delivery remains a key hurdle to effective gene therapy. We …

Amino acids from 126 to 135 of the SV40 virus T antigen act as efficient nuclear localization
signal during infection but also when fused to recombinant proteins. This peptide has been …

This study quantifies myocardial transfection following percutaneous retrograde coronary
venous delivery (RCVD) of a plasmid encoding human Del‐1. RCVD of Del‐1, GFP plasmid …

Multifunctional proteins are interesting candidates for nonviral gene transfer to and
expression in their target cells. Since at difference of viral vectors, the performance of these …

This invention provides modified recombinant Ad vectors (eg, AdE1-Vectors) undergoing
defined homologous recombination in order to create predictably rearranged genomic …