Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in shaping their progression. Many desmoplastic …

Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing
and signaling in response to altered microenvironmental conditions. In order to provide …

Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma
(PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an …

Simple Summary Prostate cancer is a malignancy that affects a high number of men all over
the world. When indolent, prostate cancer can remain silent for years without needing …

The transcriptional regulators YAP and TAZ are involved in numerous physiological
processes including organ development, growth, immunity and tissue regeneration. YAP …

Gene expression noise is known to promote stochastic drug resistance through the elevated
expression of individual genes in rare cancer cells. However, we now demonstrate that …

The dense desmoplastic and fibrotic stroma is a characteristic feature of pancreatic ductal
adenocarcinoma (PDAC), regulating disease progression, metastasis and response to …

Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with limited treatment options
and terrible long-term survival, and it is expected to become the second leading cause of …