Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …
treatment protocols based on a single vascular complication are no longer suitable for the …
T cell subsets and functions in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
Immunity and inflammation in atherosclerosis
There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …
Living macrophage-delivered tetrapod PdH nanoenzyme for targeted atherosclerosis management by ROS scavenging, hydrogen anti-inflammation, and autophagy …
Atherosclerosis, driven by chronic inflammation in the artery walls, underlies several severe
cardiovascular diseases. However, currently available anti-inflammatory-based strategies …
cardiovascular diseases. However, currently available anti-inflammatory-based strategies …
Atherosclerosis and inflammation: insights from the theory of general pathological processes
E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …
[HTML][HTML] Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice
L Wang, Y Yu, S Ni, D Li, J Liu, D Xie, HY Chu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Sclerostin inhibition demonstrated bone anabolic potential in osteogenesis
imperfecta (OI) mice, whereas humanized therapeutic sclerostin antibody romosozumab for …
imperfecta (OI) mice, whereas humanized therapeutic sclerostin antibody romosozumab for …
Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells
Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …
VEGF-A in cardiomyocytes and heart diseases
M Braile, S Marcella, L Cristinziano… - International Journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq
J Vallejo, C Cochain, A Zernecke… - Cardiovascular …, 2021 - academic.oup.com
Immune cells in atherosclerosis include T, B, natural killer (NK) and NKT cells,
macrophages, monocytes, dendritic cells (DCs), neutrophils, and mast cells. Advances in …
macrophages, monocytes, dendritic cells (DCs), neutrophils, and mast cells. Advances in …