[HTML][HTML] The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

[HTML][HTML] Micro-and nanosized carriers for nose-to-brain drug delivery in neurodegenerative disorders

R Boyuklieva, B Pilicheva - Biomedicines, 2022 - mdpi.com
Neurodegenerative disorders (NDs) have become a serious health problem worldwide due
to the rapid increase in the number of people that are affected and the constantly aging …

[HTML][HTML] Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach

X Morató, V Pytel, S Jofresa, A Ruiz… - International Journal of …, 2022 - mdpi.com
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …

Novel Flavonol Alkaloids in Green Tea: Synthesis, Detection, and Anti-Alzheimer's Disease Effect in a Transgenic Caenorhabditis elegans CL4176 Model

CH Chen, Y Yang, JP Ke, Z Yang, JY Li… - Journal of Agricultural …, 2024 - ACS Publications
Novel N-ethy-2-pyrrolidinone-substituted flavonols, myricetin alkaloids A–C (1–3), quercetin
alkaloids A–C (4a, 4b, and 5), and kaempferol alkaloids A and B (6 and 7), were prepared …

Research progress of plant‐derived natural alkaloids in central nervous system diseases

Q Zhang, Q Jiang, K Sa, J Liang, D Sun… - Phytotherapy …, 2023 - Wiley Online Library
Central nervous system (CNS) disease is one of the most important causes of human death.
Because of their complex pathogenesis, more and more attention has been paid to them. At …

[HTML][HTML] Research progress in traditional Chinese medicine in the treatment of Alzheimer's disease and related dementias

W Tan, L Qi, X Hu, Z Tan - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the world's leading cause of dementia and has become a huge
economic burden on nations and families. However, the exact etiology of AD is still …

[HTML][HTML] Anti-neuroinflammatory potential of natural products in the treatment of Alzheimer's disease

M Deng, W Yan, Z Gu, Y Li, L Chen, B He - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD) is an age-related chronic progressive neurodegenerative disease,
which is the main cause of dementia in the elderly. Much evidence shows that the onset and …

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

BC Phukan, R Roy, I Gahatraj… - Phytotherapy …, 2023 - Wiley Online Library
Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease
(PD) are characterized by the impairment of memory and motor functions, respectively …

[HTML][HTML] Huperzine—A improved animal behavior in cuprizone-induced mouse model by alleviating demyelination and neuroinflammation

H Zhang, D Wang, J Sun, Y Wang, S Wu… - International Journal of …, 2022 - mdpi.com
Huperzine A (HupA) is a natural acetylcholinesterase inhibitor (AChEI) with the advantages
of high efficiency, selectivity as well as reversibility and can exhibit significant therapeutic …

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and …

W Li, Y Rang, H Liu, C Liu - Phytotherapy Research, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the major neurological disorders causing death in the
elderly worldwide. As a neurodegenerative disease that is difficult to prevent and cure, the …