Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of
the most common gastrointestinal diseases encountered in emergency departments with no …

The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane
calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of …

Human monocytes respond to arachidonic acid, a secretory product of endothelial cells, by
activating the de novo pathway of fatty acid biosynthesis, resulting in the acquisition of a …

Background and aims Peripancreatic fat necrosis occurs frequently in necrotising
pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is …

Abstract The plasma membrane Ca 2+-ATPase (PMCA) is a ubiquitously expressed, ATP-
driven Ca 2+ pump that is critical for maintaining low resting cytosolic Ca 2+([Ca 2+] i) in all …

Acute pancreatitis (AP) is serious inflammatory disease of the pancreas. Accumulating
evidence links diabetes with severity of AP, suggesting that endogenous insulin may be …

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and
subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations …

Acute pancreatitis is currently the most common cause of hospital admission among all
nonmalignant gastrointestinal diseases. To understand the pathophysiology of the disease …

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney
Diseases to focus on research gaps and opportunities in chronic pancreatitis (CP) and its …

Key points Ca2+ signalling in different cell types in exocrine pancreatic lobules was
monitored simultaneously and signalling responses to various stimuli were directly …