Sulfur assimilation in photosynthetic organisms: molecular functions and regulations of transporters and assimilatory enzymes

H Takahashi, S Kopriva, M Giordano… - Annual review of …, 2011 - annualreviews.org
Sulfur is required for growth of all organisms and is present in a wide variety of metabolites
having distinctive biological functions. Sulfur is cycled in ecosystems in nature where …

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

TW Kensler, BD Roebuck, GN Wogan… - Toxicological …, 2011 - academic.oup.com
Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous
contaminants of the human food supply throughout the economically developing world. The …

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative …

DD Zhang, M Hannink - Molecular and cellular biology, 2003 - Am Soc Microbiol
A common feature of diverse chemopreventive agents is the ability to activate expression of
a genetic program that protects cells from reactive chemical species that, if left unchecked …

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

DD Zhang, SC Lo, JV Cross… - … and cellular biology, 2004 - Am Soc Microbiol
The bZIP transcription factor Nrf2 controls a genetic program that protects cells from
oxidative damage and maintains cellular redox homeostasis. Keap1, a BTB-Kelch protein, is …

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

H Kumar, IS Kim, SV More, BW Kim, DK Choi - Natural product reports, 2014 - pubs.rsc.org
Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

Mechanistic studies of the Nrf2-Keap1 signaling pathway

DD Zhang - Drug metabolism reviews, 2006 - Taylor & Francis
Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …

Stress induced production of plant secondary metabolites in vegetables: functional approach for designing next generation super foods

D Sharma, B Shree, S Kumar, V Kumar… - Plant Physiology and …, 2022 - Elsevier
Plant secondary metabolites are vital for human health leading to the gain the access to
natural products. The quality of crops is the result of the interaction of different biotic and …

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

E Balogun, M Hoque, P Gong, E Killeen… - Biochemical …, 2003 - portlandpress.com
The transcription factor Nrf2, which normally exists in an inactive state as a consequence of
binding to a cytoskeleton-associated protein Keap1, can be activated by redox-dependent …

Antioxidant Activities and Anthocyanin Content of Fresh Fruits of Common Fig (Ficus carica L.)

A Solomon, S Golubowicz, Z Yablowicz… - Journal of agricultural …, 2006 - ACS Publications
Fig fruit has been a typical component in the health-promoting Mediterranean diet for
millennia. To study the potential health-promoting constituents of fig fruits, six commercial fig …

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

JW Fahey, X Haristoy, PM Dolan… - Proceedings of the …, 2002 - National Acad Sciences
Gastric infection with Helicobacter pylori is a cosmopolitan problem, and is especially
common in developing regions where there is also a high prevalence of gastric cancer …