Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells.
In humans, aneuploidy is associated with various pathologies, including cancer, which …

The immunotherapeutic treatment of various cancers with an increasing number of immune
checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Genomic instability consists of a range of genetic alterations within the genome that
contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Chromosomal instability (CIN) is one of the major forms of genomic instability in various
human cancers and is recognized as a common hallmark of tumorigenesis and …

A common assumption is that human chromosomes carry equal chances of mis-segregation
during compromised cell division. Human chromosomes vary in multiple parameters that …