Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the
homeostasis of all the tissues, including the brain, where it harmonizes nerve signal …

Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …

Plastics breaking down of larger plastics into smaller ones (microplastics and nanoplastic)
as potential threats to the ecosystem. Previous studies demonstrate that the central nervous …

Cancer is the second leading cause of death worldwide and accounted for an estimated 9.6
million deaths, or 1 in 6 deaths, in 2018. Despite recent advances in cancer prevention …

The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …

Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest
category of drug targets, following enzymes and receptors. The transient receptor potential …

Ovarian cancer stands as the prevailing gynecologic malignancy, afflicting over 313,959
individuals annually worldwide, accompanied by more than 207,252 fatalities. Perturbations …

Renal ischemia-reperfusion (IR) injury triggers a cascade of signaling reactions involving an
increase in Ca2+ charge and reactive oxygen species (ROS) levels resulting in necrosis …

Oxidative stress induced by brain ischemia upregulates transient receptor potential
melastatin-like-7 (TRPM7) expression and currents, which could contribute to neurotoxicity …

After spinal cord injury (SCI), secondary injuries including blood cells infiltration followed by
the production of inflammatory mediators are led by blood-spinal cord barrier (BSCB) …