The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

N 6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic
messenger RNA (mRNA) and plays critical roles in RNA biology. The function of this …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …

The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings
sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding …

Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

Histones are frequently decorated with covalent modifications. These histone modifications
are thought to be involved in various chromatin-dependent processes including …