Acetyl-CoA carboxylases and diseases
Y Wang, W Yu, S Li, D Guo, J He, Y Wang - Frontiers in oncology, 2022 - frontiersin.org
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …
Tyrosine kinase inhibitors in cancer: breakthrough and challenges of targeted therapy
C Pottier, M Fresnais, M Gilon, G Jérusalem… - Cancers, 2020 - mdpi.com
Receptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer
cell growth and metastasis. During the last two decades, several molecules targeting RTKs …
cell growth and metastasis. During the last two decades, several molecules targeting RTKs …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
The role of mTOR signaling as a therapeutic target in cancer
NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
KRAS: From undruggable to a druggable Cancer Target
D Uprety, AA Adjei - Cancer treatment reviews, 2020 - Elsevier
RAS is the most frequently mutated oncogene in human cancers, with mutations in about
30% of all cancers. RAS exists in three different isoforms (K-RAS, H-RAS and N-RAS) with …
30% of all cancers. RAS exists in three different isoforms (K-RAS, H-RAS and N-RAS) with …
The role of PI3K/Akt and ERK in neurodegenerative disorders
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
Non-Smad signaling pathways of the TGF-β family
YE Zhang - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and structurally related factors use several intracellular
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …
signaling pathways in addition to Smad signaling to regulate a wide array of cellular …
Kinase-targeted cancer therapies: progress, challenges and future directions
KS Bhullar, NO Lagarón, EM McGowan, I Parmar… - Molecular cancer, 2018 - Springer
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy
S Qin, A Li, M Yi, S Yu, M Zhang, K Wu - Journal of hematology & oncology, 2019 - Springer
Angiogenesis has always been the topic of major scientific interest in the field of malignant
tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by …
tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by …