Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in other …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with
DNA methylation and silencing of genes involved in tumor suppression. In this study, we …

Heart failure (HF) is a leading cause of morbidity and mortality in the United States and
worldwide. As a multifactorial syndrome with unpredictable clinical outcomes, identifying the …

There is increasing evidence that toxicant exposure can alter DNA methylation profile, one
of the main epigenetic mechanisms, particularly during embryogenesis when DNA …

Introduction: The rapid progress of bioinformatics and high-throughput screening techniques
in recent years has led to the identification of many candidate genes and small-molecule …

During early embryogenesis, the vertebrate embryo extends from anterior to posterior
because of the progressive addition of cells from a posteriorly localized neuromesodermal …

Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression
and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a …

Background Multicellular organisms require precise gene regulation during ontogeny, and
epigenetic modifications, such as DNA methylation and histone modification, facilitate this …

In vertebrates, DNA methylation predominantly occurs at CG dinucleotides however,
widespread non-CG methylation (mCH) has been reported in mammalian embryonic stem …