The fundamental basis of muscle contraction 'the sliding filament model'(;) and the 'swinging,
tilting crossbridge-sliding filament mechanism'(;) nucleated a field of research that has …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Poor access to human left ventricular myocardium is a significant limitation in the study of
heart failure (HF). Here, we utilise a carefully procured large human heart biobank of …

About half of hypertrophic and dilated cardiomyopathies cases have been recognized as
genetic diseases with mutations in sarcomeric proteins. The sarcomeric proteins are …

Despite bulk magnetic materials possess multidomain structure, single domain magnetic
crystals can be obtained at the nanoscale, which display superparamagnetic behavior with …

Background Recent studies suggest that mavacamten (Myk461), a small myosin‐binding
molecule, decreases hypercontractility in myocardium expressing hypertrophic …

Omecamtiv mecarbil (OM) is a promising novel drug for improving cardiac contractility. We
tested the therapeutic range of OM and identified previously unrecognized side effects. The …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is
mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these …

Decreased cardiac myosin-binding protein C (cMyBPC) expression due to inheritable
mutations is thought to contribute to the hypertrophic cardiomyopathy (HCM) phenotype …

Heart failure (HF) is a rapidly growing pandemic while medical treatment options remain
limited. Omecamtiv mecarbil (OM) is a novel HF drug that directly targets the myosin heads …