Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic
phosphorylation during transcription, and the different phosphorylation patterns that …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

All RNA species in yeast cells are subject to turnover. Work over the past 20 years has
defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs …

Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …