Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …

Background The loss of tumor antigens and depletion of CD8 T cells caused by the PD-1/PD-
L1 pathway are important factors for tumor immune escape. In recent years, there has been …

CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble
form. CXCR6 is a marker for resident memory T (TRM) cells that plays a role in …

The success of anticancer treatments relies on a long-term response which can be mediated
by the immune system. Thus, the concept of immunogenic cell death (ICD) describes the …

Background Glioblastoma (GBM) is the most aggressive type of primary brain tumor and is
often resistant to current therapies. Tumor microenvironment-centered therapies may …

Abstract The C–X–C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR−
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …

Although radiotherapy (RT) has achieved great success in the treatment of non-small cell
lung cancer (NSCLC), local relapses still occur and abscopal effects are rarely seen even …

Chemokines are chemotactic cytokines whose canonical functions govern movement of
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …