Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …

Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

Sequence-specific transcription factors (TFs) are the key effectors of eukaryotic gene control
and they regulate hundreds to thousands of downstream genes. Of particular interest are …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …

Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …

Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is
particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays …