Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

Objective Fine particulate matter (PM2. 5) is a source of pollution worldwide, that causes
inflammation and liver fibrosis. Melatonin, as the predominant hormone secreted by the …

Intestinal inflammation represented by inflammatory bowel disease (IBD) has become a
global epidemic disease and the number of patients with IBD continues to increase. This …

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Introduction Currently, revealing how to prevent and control hyperuricemia has become an
essential public health issue. Sulforaphane has a wide range of applications in the …

Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …