Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

The past decade has seen an explosion in the field of in vitro disease modelling, in
particular the development of organoids. These self-organizing tissues derived from stem …

Defective placentation is the underlying cause of various pregnancy complications, such as
severe intrauterine growth restriction and preeclampsia. However, studies on human …

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a
dish. While mouse models and cell lines have furthered our understanding of liver biology …

Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …

Image-based phenotypic screening relies on the extraction of multivariate information from
cells cultured under a large variety of conditions. Technical advances in high-throughput …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

The capacity of the 3D-organoid cultures to resemble a near-physiological tissue
organization and to mimic–to a certain degree–organ functionality, make organoids an …