Long-term survival after kidney transplantation
S Hariharan, AK Israni… - New England Journal of …, 2021 - Mass Medical Soc
Long-Term Survival after Kidney Transplantation This review discusses demographics,
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …
survival, and risks in kidney transplantation since the mid-1990s. It addresses postoperative …
The promise of organ and tissue preservation to transform medicine
The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …
each year globally and create public health benefits on par with curing cancer. Unmet needs …
[HTML][HTML] Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial
SA Hosgood, CJ Callaghan, CH Wilson, L Smith… - Nature medicine, 2023 - nature.com
Kidney transplantation is the optimal treatment for end-stage renal disease, but it is still
severely limited by a lack of suitable organ donors. Kidneys from donation after circulatory …
severely limited by a lack of suitable organ donors. Kidneys from donation after circulatory …
[HTML][HTML] Hypothermia or machine perfusion in kidney donors
D Malinoski, C Saunders, S Swain… - … England Journal of …, 2023 - Mass Medical Soc
Background Therapeutic hypothermia in brain-dead organ donors has been shown to
reduce delayed graft function in kidney recipients after transplantation. Data are needed on …
reduce delayed graft function in kidney recipients after transplantation. Data are needed on …
[HTML][HTML] Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model
Banking cryopreserved organs could transform transplantation into a planned procedure
that more equitably reaches patients regardless of geographical and time constraints …
that more equitably reaches patients regardless of geographical and time constraints …
Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial
I Jochmans, A Brat, L Davies, HS Hofker… - The Lancet, 2020 - thelancet.com
Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …
[HTML][HTML] Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial
R Ravikumar, W Jassem, H Mergental, N Heaton… - American Journal of …, 2016 - Elsevier
The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …
preservation and ischemia–reperfusion injury. We present the first patients transplanted …
Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial
A Ardehali, F Esmailian, M Deng, E Soltesz, E Hsich… - The Lancet, 2015 - thelancet.com
Summary Background The Organ Care System is the only clinical platform for ex-vivo
perfusion of human donor hearts. The system preserves the donor heart in a warm beating …
perfusion of human donor hearts. The system preserves the donor heart in a warm beating …
[HTML][HTML] Practical recommendations for long-term management of modifiable risks in kidney and liver transplant recipients: a guidance report and clinical checklist by …
JM Neuberger, WO Bechstein, DRJ Kuypers… - …, 2017 - journals.lww.com
Short-term patient and graft outcomes continue to improve after kidney and liver
transplantation, with 1-year survival rates over 80%; however, improving longer-term …
transplantation, with 1-year survival rates over 80%; however, improving longer-term …
[HTML][HTML] Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …
inflammatory responses that can result in the loss of kidney graft viability. However, the long …