Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the
mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH …

Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
the third cancer-related cause of death worldwide. In recent years, several systemic therapy …

Simple Summary One hundred years ago, it was discovered that some cancer cells have a
different metabolism from normal cells. This alternative metabolism is called the Warburg …

Mitochondria are semiautonomous doubly membraned intracellular components of cells.
The organelle comprises of an external membrane, followed by coiled structures within the …

Evidence recently showed that pleiotropic cytokine interferon-gamma (IFN-γ) in the tumor
microenvironment (TME) plays a positive role in hepatocellular carcinoma (HCC) …

Tumor cells with damaged mitochondria undergo metabolic reprogramming, but gene
therapy targeting mitochondria has not been comprehensively reported. In this study …

Hepatocellular carcinoma (HCC) is a malignancy worldwide with one of the worst
prognoses. Emerging studies have revealed that long noncoding RNAs (lncRNAs) …

Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer-related
deaths and the most frequently diagnosed cancer type. CRC risk can be preventable by …