Vertically transferred immunity in neonates: mothers, mechanisms and mediators

M Albrecht, PC Arck - Frontiers in Immunology, 2020 - frontiersin.org
Over the last years, an increasing number of outbreaks of vaccine-preventable infectious
diseases has been reported. Besides elderly and immunocompromised individuals …

Global perspectives on immunization during pregnancy and priorities for future research and development: an international consensus statement

B Abu-Raya, K Maertens, KM Edwards… - Frontiers in …, 2020 - frontiersin.org
Immunization during pregnancy has been recommended in an increasing number of
countries. The aim of this strategy is to protect pregnant women and infants from severe …

Association of COVID-19 vaccination during pregnancy with incidence of SARS-CoV-2 infection in infants

EØ Carlsen, MC Magnus, L Oakley, DB Fell… - JAMA internal …, 2022 - jamanetwork.com
Importance Pregnant women are recommended to receive COVID-19 vaccination to reduce
risk of severe COVID-19. Whether vaccination during pregnancy also provides passive …

Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

EA Bordt, LL Shook, C Atyeo, KM Pullen… - Science translational …, 2021 - science.org
There is a persistent bias toward higher prevalence and increased severity of coronavirus
disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex …

Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health

KJ Baines, RC West - Biology of reproduction, 2023 - academic.oup.com
The differences between males and females begin shortly after birth, continue throughout
prenatal development, and eventually extend into childhood and adult life. Male embryos …

The adaptive immune system in early life: The shift makes it count

DKJ Pieren, MC Boer, J de Wit - Frontiers in immunology, 2022 - frontiersin.org
Respiratory infectious diseases encountered early in life may result in life-threatening
disease in neonates, which is primarily explained by the relatively naive neonatal immune …

Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers

M Vono, CS Eberhardt, F Auderset, B Mastelic-Gavillet… - Cell reports, 2019 - cell.com
Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to
vaccination. The mechanisms of this inhibition are still debated. Using murine early-life …

Vaccination in pregnancy against pertussis: a consensus statement on behalf of the global pertussis initiative

B Abu-Raya, K Forsyth, SA Halperin, K Maertens… - Vaccines, 2022 - mdpi.com
Highlights-Vaccination against pertussis in pregnancy is safe for pregnant women and
newborns.-Vaccination against pertussis during the second or early third trimester of …

Maternal immunization: nature meets nurture

A Saso, B Kampmann - Frontiers in microbiology, 2020 - frontiersin.org
Vaccinating women in pregnancy (ie, maternal immunization) has emerged as a promising
tool to tackle infant morbidity and mortality worldwide. This approach nurtures a 'gift of …

Neonatal immunization: rationale, current state, and future prospects

E Whittaker, D Goldblatt, P McIntyre, O Levy - Frontiers in immunology, 2018 - frontiersin.org
Infections take their greatest toll in early life necessitating robust approaches to protect the
very young. Here, we review the rationale, current state, and future research directions for …