It has been proven that exposure to some drugs even before gestation had
transgenerational effects. To investigate the changes which induced by parental morphine …

Drug withdrawal-associated aversive memories trigger relapse to drug-seeking behavior.
Corticotrophin-releasing factor (CRF) is an important mediator of the reinforcing properties of …

Orexinergic system is involved in primary rewards; the neural circuit of the ventral tegmental
area (VTA), nucleus accumbens (NAc), prefrontal cortex and amygdala represents …

Propofol addiction has been detected in human and rats, which may be facilitated by stress.
Corticotropin-releasing factor (CRF) acts through CRF receptor-1 (CRF1R) and CRF2R, and …

Intense associative memories develop between drug-paired contextual cues and the drug
withdrawal associated aversive feeling. They have been suggested to contribute to the high …

Corticotropin-releasing factor (CRF) acts as neuro-regulator of the behavioral and emotional
integration of environmental and endogenous stimuli associated with drug dependence …

Previous studies in our laboratory showed an interaction between the GABAergic and opioid
systems involved in the analgesic effect of baclofen (BAC). Furthermore, it is known that sex …

Morphine has been shown to increase the expression of brain‐derived neurotrophic factor
(BDNF) in the brain. However, little is known about the effect of conditioned naloxone …

Animal studies demonstrate that peripubertal social stress markedly increases the risk for
subsequent substance use in adulthood. However, whether non‐social stress has a similar …

Drug addiction is characterized by maladaptive neural plasticity, particularly in vulnerable
individuals exposed to drugs of abuse. Epigenetic factors include environmental influences …