Screening in both healthy and high-risk populations offers the opportunity to detect cancer
early and with an increased opportunity for treatment and curative intent. Currently, a …

Detection of mutations in hereditary breast and ovarian cancer-related BRCA1 and BRCA2
genes is an effective method of cancer prevention and early detection. Different ethnic and …

Background The purpose of this consensus guideline is to outline recommendations for
genetic testing that medical professionals can use to assess hereditary risk for breast …

Background In healthy BRCA1/2 mutation carriers, bilateral risk-reducing mastectomy
(BRRM) strongly reduces the risk of developing breast cancer (BC); however, no clear …

Clinical interpretation of missense variants is challenging because the majority identified by
genetic testing are rare and their functional effects are unknown. Consequently, most …

Importance Bilateral mastectomy is increasingly used to treat unilateral breast cancer.
Because it may have medical and psychosocial complications, a better understanding of its …

Importance Nipple-sparing mastectomy (NSM) offers superior cosmetic outcomes and has
been gaining wide acceptance; however, its role among patients withBRCAmutations …

Background: Previous studies have reported a breast cancer (BC) risk reduction of
approximately 50% after risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 …

Background Molecular characterization of breast cancer allows subtype-directed
interventions. Estrogen receptor (ER) is the longest-established molecular marker. Methods …

Background There are few large-scale studies that have examined outcomes for BRCA1/2
carriers who have undergone nipple-sparing mastectomy (NSM). The objective of our study …