Mechanisms of viral inflammation and disease in humans
JL Casanova, L Abel - Science, 2021 - science.org
Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
JL Casanova, L Abel - Cell, 2022 - cell.com
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
[HTML][HTML] Zoonotic spillover: Understanding basic aspects for better prevention
JH Ellwanger, JAB Chies - Genetics and Molecular Biology, 2021 - SciELO Brasil
The transmission of pathogens from wild animals to humans is called “zoonotic spillover”.
Most human infectious diseases (60-75%) are derived from pathogens that originally …
Most human infectious diseases (60-75%) are derived from pathogens that originally …
[HTML][HTML] Genetic adaptation and neandertal admixture shaped the immune system of human populations
H Quach, M Rotival, J Pothlichet, YHE Loh… - Cell, 2016 - cell.com
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …
extent of population differences in immune responses and their genetic and evolutionary …
Follicular Helper CD4 T Cells (TFH)
S Crotty - Annual review of immunology, 2011 - annualreviews.org
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …
[HTML][HTML] Making human immune systems more interpretable through systems immunology
The human immune system is a distributed system of specialized cell populations with
unique functions that collectively give rise to immune responses to infections and during …
unique functions that collectively give rise to immune responses to infections and during …
[HTML][HTML] Severe influenza pneumonitis in children with inherited TLR3 deficiency
HK Lim, SXL Huang, J Chen, G Kerner… - The Journal of …, 2019 - ncbi.nlm.nih.gov
Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency
D Bogunovic, M Byun, LA Durfee, A Abhyankar… - Science, 2012 - science.org
ISG15 is an interferon (IFN)-α/β–inducible, ubiquitin-like intracellular protein. Its conjugation
to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe …
to various proteins (ISGylation) contributes to antiviral immunity in mice. Here, we describe …
Genomewide association study of leprosy
FR Zhang, W Huang, SM Chen, LD Sun… - … England Journal of …, 2009 - Mass Medical Soc
Background The narrow host range of Mycobacterium leprae and the fact that it is refractory
to growth in culture has limited research on and the biologic understanding of leprosy. Host …
to growth in culture has limited research on and the biologic understanding of leprosy. Host …
[HTML][HTML] Viral evasion and subversion of pattern-recognition receptor signalling
AG Bowie, L Unterholzner - Nature Reviews Immunology, 2008 - nature.com
The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides
the host with the ability to detect and respond to infection by viruses and other …
the host with the ability to detect and respond to infection by viruses and other …