determination and the implementation of preventive, diagnostic or therapeutic medical
strategies. However, the ESC Guidelines do not override in any way whatsoever the …

Part II of the consensus guidelines updates the recommendations for the periprocedural
management of thrombotic and bleeding risks in patients who require image-guided …

Periprocedural management of anticoagulation is a common clinical conundrum that
involves a multidisciplinary team, cuts across many specialties, and varies greatly between …

Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the
oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori …

The direct acting oral anticoagulants (DOAC s), including dabigatran, rivaroxaban,
apixaban, and edoxaban, have favorable pharmacokinetic and pharmacodynamic …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Anticoagulant drugs (ie, unfractionated heparin, low-molecular-weight heparins, vitamin K
antagonists, and direct oral anticoagulants) are widely employed in preventing and treating …

Older adults, the fastest growing population, represent almost 50% of all users of direct oral
anticoagulants (DOACs). Unfortunately, we have very little relevant pharmacological and …

Background Warfarin use can trigger the occurrence of bleeding independently or as a
result of a drug–drug interaction when used in combination with nonsteroidal anti …

The presence of cirrhosis poses an increased risk of both thrombosis and bleeding in
individuals with chronic liver disease. This duality is a result of a dynamic disequilibrium …