Significance: Persulfides/polysulfides are sulfur-catenated molecular species (ie, R-Sn-R′,
n> 2; R-Sn-H, n> 1, with R= cysteine, glutathione, and proteins), such as cysteine persulfide …

For decades, the major focus of redox biology has been oxygen, the most abundant element
on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial …

In an attempt to understand the cellular mechanisms of H 2 S signalling, recent research has
focused on supersulfide (ie, alkyl and inorganic hydropersulfide) formation and subsequent …

The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …

Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are
increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP) …

Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox
regulators and closely linked to H2S signaling. However, the study of these species is still …

Oxygen is critical for all metazoan organisms on the earth and impacts various biological
processes in physiological and pathological conditions. While oxygen-sensing systems …

Redox-responsive hydropersulfide prodrugs are designed to enable a more controllable
and efficient hydropersulfide (RSSH) supply and to thoroughly explore their biological and …

Innate immunity plays an important role in host defense against microbial infections. It also
participates in activation of acquired immunity through cytokine production and antigen …

Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that serve a foundational role in
the efficient and accurate translation of genetic information from messenger RNA to proteins …