Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The response of immune cells to pathogens is often associated with changes in the flux
through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to …

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …

ABSTRACT Introduction Liver X receptors (LXRs) are master regulators of atherogenesis.
Their anti-atherogenic potential has been attributed to their role in the inhibition of …

Monocyte and macrophage phenotypic diversity is important in atherogenesis. More work is
needed to define consistent marker sets for the different foam cell phenotypes in …

Transport of phospholipids across cell membranes plays a key role in a wide variety of
biological processes. These include membrane biosynthesis, generation and maintenance …