Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

JS Fleishman, S Kumar - Signal Transduction and Targeted Therapy, 2024 - nature.com
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …

Astragalus polysaccharide attenuates nonalcoholic fatty liver disease through THDCA in high-fat diet-fed mice

N Zheng, H Wang, W Zhu, Y Li, H Li - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Astragalus polysaccharide (APS) extracted from
Astragalus membranaceus (Fisch.) Bunge was proven to be effective in preventing high-fat …

Effects of different types of dietary fibers on lipid metabolism and bile acids in weaned piglets

Y Hu, D He, B Yu, D Chen - Animals, 2023 - mdpi.com
Simple Summary Dietary fiber, as an essential nutrient, is very important for the health of
animals and it is necessary to study the effects of dietary fiber on animal physiology and its …

[HTML][HTML] The Role of Gut Microbiota associated Metabolites in Digestive Disorders

N Li, C Zhao, P Zhang, S Wu, X Dou, S Xu… - Engineered …, 2024 - Elsevier
The gut has been a focal point in the research of digestive system disorders. The internal
microbiota generates metabolites that function as signaling molecules and substrates …

Inhibition of PCSK9 prevents and alleviates cholesterol gallstones through PPARα-mediated CYP7A1 activation

Z Chen, W Shao, Y Li, X Zhang, Y Geng, X Ma, B Tao… - Metabolism, 2024 - Elsevier
Background & aims Dysregulated cholesterol metabolism is the major factor responsible for
cholesterol gallstones (CGS). Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a …

Taohe Chengqi decoction alleviated metabolic-associated fatty liver disease by boosting branched chain amino acids catabolism in the skeletal muscles of type 2 …

Z Yuan, H Qiao, Z Wang, H Wang, M Han, W Zhang… - Phytomedicine, 2024 - Elsevier
Objective Metabolic-associated fatty liver disease (MAFLD) is the most prevalent liver
disease, whereas type 2 diabetes mellitus (T2DM) is considered an independent risk factor …

Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota

X Bai, J Deng, Z Duan, R Fu, C Zhu, D Fan - Phytomedicine, 2024 - Elsevier
Background Gastrointestinal mucositis stands as one of the most severe side effects of
irinotecan (CPT-11). however, only palliative treatment is available at present. Therefore …

[HTML][HTML] Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at …

C Liu, D Huang, X Sheng, J Zhu, S Dong… - Ecotoxicology and …, 2024 - Elsevier
The available information regarding the impact of antimony (Sb), a novel environmental
pollutant, on the intestinal microbiota and host health is limited. In this study, we conducted …

[HTML][HTML] Supplementation with dimethylglycine sodium salt improves lipid metabolism disorder in intrauterine growth-retarded pigs

K Bai, L Jiang, T Wang - Animal Nutrition, 2024 - Elsevier
Intrauterine growth retardation (IUGR) contributes to the increased incidence of metabolic
syndromes in adulthood, yet the mechanisms underlying lipid metabolism disorders in IUGR …

Hydroxytyrosol Alleviates Intestinal Oxidative Stress by Regulating Bile Acid Metabolism in a Piglet Model

X Wen, F Wan, R Zhong, L Chen, H Zhang - International Journal of …, 2024 - mdpi.com
Infants and young animals often suffer from intestinal damage caused by oxidative stress,
which may adversely affect their overall health. Hydroxytyrosol, a plant polyphenol, has …