[HTML][HTML] Inflammatory bowel disease treatments and predictive biomarkers of therapeutic response

DA Elhag, M Kumar, M Saadaoui, AK Akobeng… - International journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …

IBD disease-modifying therapies: insights from emerging therapeutics

NG Kotla, Y Rochev - Trends in Molecular Medicine, 2023 - cell.com
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …

[HTML][HTML] Role of biomarkers in the diagnosis and treatment of inflammatory bowel disease

K Wagatsuma, Y Yokoyama, H Nakase - Life, 2021 - mdpi.com
The number of patients with inflammatory bowel disease (IBD) is increasing worldwide.
Endoscopy is the gold standard to assess the condition of IBD. The problem with this …

[HTML][HTML] The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease

AC Finney, S Das, D Kumar, MP McKinney… - Frontiers in …, 2023 - frontiersin.org
Therapeutic approaches that lower circulating low-density lipoprotein (LDL)-cholesterol
significantly reduced the burden of cardiovascular disease over the last decades. However …

Understanding the mechanistic pathways and clinical aspects associated with protein and gene based biomarkers in breast cancer

T Behl, A Kumar, A Sehgal, S Singh, N Sharma… - International Journal of …, 2023 - Elsevier
Cancer is one of the most widespread and severe diseases with a huge mortality rate. In
recent years, the second-leading mortality rate of any cancer globally has been breast …

Drugst. One—a plug-and-play solution for online systems medicine and network-based drug repurposing

A Maier, M Hartung, M Abovsky… - Nucleic Acids …, 2024 - academic.oup.com
In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …

[HTML][HTML] Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

HE Specht, N Mannig, M Belheouane… - Frontiers in …, 2022 - frontiersin.org
Introduction Anorexia nervosa (AN) is an often chronic and debilitating psychiatric disease
whose etiology is not completely understood. Recently, a potential role of inflammation has …

[HTML][HTML] Predictive biomarkers for anti-TNF alpha therapy in IBD patients

M Kumar, S Murugesan, N Ibrahim, M Elawad… - Journal of Translational …, 2024 - Springer
Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by
severe gut inflammation, commonly presenting as Crohn's disease, ulcerative colitis or …

[HTML][HTML] Changes in salivary parameters of oral immunity after biologic therapy for inflammatory bowel disease

K Nijakowski, R Rutkowski, P Eder, K Korybalska… - Life, 2021 - mdpi.com
We previously observed that inflammatory bowel disease (IBD) may compromise oral host
defense, as assessed by decreased salivary levels of immunoglobulin A (IgA) and …

[HTML][HTML] Paenibacillus exopolysaccharide repairs GI inflammation by suppressing MAPK and NF-κB and restoring lipid production in Caco-2 cell line

J Zhang, ZQ Li, RJ Zheng, JJ Jiang, DD Li… - Journal of Functional …, 2023 - Elsevier
Paenibacillus polymyxa exopolysaccharide PYQ1-EPS is a homogeneous glucomannan-
type polysaccharide. In this work, its stability and reparative effects on the in vitro model of …