Mitochondria have been proposed as targets for toxicity in amyotrophic lateral sclerosis
(ALS), a progressive, fatal adult-onset neurodegenerative disorder characterized by the …

Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene
(HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We …

In Huntington's disease (HD), the uninterrupted CAG repeat length, but not the
polyglutamine length, predicts disease onset. However, the underlying pathobiology …

Huntington's disease (HD) is characterized by a progressive course of disease until death
15–20 years after the first symptoms occur and is caused by a mutation with expanded CAG …

5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine.
While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is …

The development of animal models of Huntington disease (HD) has enabled studies that
help define the molecular aberrations underlying the disease. The BACHD and YAC128 …

Post-translational modification of proteins by the lipid palmitate is critical for protein
localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl …

Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …

Background: Some promising treatments for Huntington's disease (HD) may require pre-
clinical testing in large animals. Minipig is a suitable species because of its large …

The first 17 amino acids of Huntington's disease (HD) protein, huntingtin, comprise an
amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum …