Huntington's disease (HD) is a hereditary and fatal disorder caused by an expanded CAG
triplet repeat in the HD gene, resulting in a mutant form of the protein huntingtin. Wild‐type …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
expansion of a translated CAG repeat in the N terminus of the huntingtin (htt) protein. Here …

Ubiquitination of misfolded proteins, a common feature of many neurodegenerative
diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of …

The structure and function of spines and excitatory synapses are under the dynamic control
of multiple signalling networks. Although tyrosine phosphorylation is involved, its regulation …

The identification of the mutation causing Huntington's disease (HD) has led to the
generation of a large number of mouse models. These models are used to further enhance …

The YAC128 mouse recapitulates many of the clinical features of Huntington disease (HD),
including selective neuropathology with neuronal loss. Here we investigate whether …

Huntington's disease (HD) is a progressive neurodegenerative disorder that generally
begins in middle age with abnormalities of movement, cognition, personality, and mood …

Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG
repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive …

A number of mouse models expressing mutant huntingtin (htt) with an expanded
polyglutamine (polyQ) domain are useful for studying the pathogenesis of Huntington's …