Huntington's disease (HD) is a progressive neurodegenerative disease caused by the
insertion of an expanded polyglutamine sequence within the huntingtin protein. This …

The present study describes evaluation of epigenetic regulation by a small molecule as the
therapeutic potential for treatment of Huntington's disease (HD). We identified 5-allyloxy-2 …

Huntington disease (HD) is one of several fatal neurodegenerative disorders associated
with misfolded proteins. Here, we report a novel method for the sensitive detection of …

In this review, we explore the similarities and differences in the behavioural neurobiology
found in the mouse models of Huntington's disease (HD) and the human disease state. The …

Ever since its original description by George Huntington in 1872, Huntington's disease (HD)
has been known as one of the most devastating inherited neurodegenerative disorders …

Transcriptional dysregulation caused by expanded polyglutamines (polyGlns) in huntingtin
(htt) may be central to cell-autonomous mechanisms for neuronal cell death in Huntington's …

Abstract Indoleamine 2, 3 dioxygenase (Ido1), the first and rate‐limiting enzyme of the
kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in …

Transgenic mouse models of Huntington's disease (HD), a neurodegenerative condition
caused by a single gene mutation, have been transformative in their ability to reveal the …

Intraneuronal protein aggregates of the mutated huntingtin in Huntington's disease (HD)
brains suggest an overload and/or dysfunction of the ubiquitin–proteasome system (UPS) …

Highlighting advances in the discovery and development of new drug therapies for
neurodegenerative disorders, Neurobiology of Huntington's Disease focuses on the many …