A data-driven computational model for engineered cardiac microtissues
Engineered heart tissues (EHTs) present a potential solution to some of the current
challenges in the treatment of heart disease; however, the development of mature, adult-like …
challenges in the treatment of heart disease; however, the development of mature, adult-like …
[HTML][HTML] Geometry and length control of 3D engineered heart tissues using direct laser writing
MÇ Karakan, JK Ewoldt, AJ Segarra, S Sundaram… - Lab on a Chip, 2024 - pubs.rsc.org
Geometry and mechanical characteristics of the environment surrounding the Engineered
Heart Tissues (EHT) affect their structure and function. Here, we employed a 3D tissue …
Heart Tissues (EHT) affect their structure and function. Here, we employed a 3D tissue …
Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues
SJ DePalma, J Jillberto, AE Stis, DD Huang, J Lo… - BioRxiv, 2023 - biorxiv.org
The mechanical function of the myocardium is defined by cardiomyocyte contractility and the
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …
Generating in-silico Models of Engineered Heart Tissues: The Importance of Using Length-Dependent Activation
Engineered heart tissues (EHTs) are a promising technology to improve cardiac disease
treatment. However, manufacturing EHTs with mature iPSC-CMs remains a challenge due …
treatment. However, manufacturing EHTs with mature iPSC-CMs remains a challenge due …