Full-length SMART-seq single-cell RNA sequencing can be used to measure gene
expression at isoform resolution, making possible the identification of specific isoform …

Neuronal maturation requires dramatic morphological and functional changes, but the
molecular mechanisms governing this process are not well understood. Here, we studied …

Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …

The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …

Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent
changes in plasticity. Here, we develop a strategy combining compartment-specific …

Retinal photoreceptors have a distinct transcriptomic profile compared to other neuronal
subtypes, likely reflecting their unique cellular morphology and function in the detection of …

The scarcity of embryonic/foetal material as a resource for direct study means that there is
still limited understanding of human retina development. Here, we present an integrated …

Combinatorially, intron excision within a given nascent transcript could proceed down any of
thousands of paths, each of which would expose different dynamic landscapes of cis …

The Rbfox family of splicing factors regulate alternative splicing during animal development
and in disease, impacting thousands of exons in the maturing brain, heart and muscle …

Protein phosphatases are major regulators of signal transduction and they are involved in
key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we …