The specification of synaptic properties is fundamental for the function of neuronal circuits."
Terminal selector" transcription factors coordinate terminal gene batteries that specify cell …

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by aberrant alternative
splicing (AS). Nuclear loss and cytoplasmic accumulation of the splicing factor TDP-43 in …

Severity of neurobehavioral deficits in children born from adverse pregnancies, such as
maternal alcohol consumption and diabetes, does not always correlate with the adversity's …

Alternative Splicing (AS) programs serve as instructive signals of cell type specificity,
particularly within the brain, which comprises dozens of molecularly and functionally distinct …

Pre-mRNA splicing is performed by the spliceosome, a dynamic macromolecular complex
consisting of five small uridine-rich ribonucleoprotein complexes (the U1, U2, U4, U5, and …

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric
disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during …

Background Alternative splicing is a key mechanism underlying cellular differentiation and a
driver of complexity in mammalian neuronal tissues. However, understanding of which …

Highlights•Alternative splicing is dynamic and supports all stages of neuronal
function.•Studies reveal molecular mechanisms that direct cell-specific exon …

Genomic regulatory elements active in the developing human brain are notably enriched in
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …

Recent genetic studies of neurodevelopmental disorders point to synaptic proteins and ion
channels as key contributors to disease pathogenesis. Although many of these proteins …