Diverse cell types in the central nervous system (CNS) are generated by a relatively small
pool of neural stem cells during early development. Spatial and temporal regulation of stem …

THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability
Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export complex (TREX) …

The expression of genetic material governs brain development, differentiation, and function,
and targeted manipulation of gene expression is required to understand contributions of …

Balanced mRNA isoform diversity and abundance are spatially and temporally regulated
throughout cellular differentiation. The proportion of expressed isoforms contributes to cell …

Alternative pre‐mRNA splicing generates multiple mRNA isoforms of different structures and
functions from a single gene. While the prevalence of alternative splicing control is widely …

Animals require different types of muscle for survival, for example for circulation, motility,
reproduction and digestion. Much emphasis in the muscle field has been placed on …

Background Microexons, exons that are≤ 30 nucleotides, are a highly conserved and
dynamically regulated set of cassette exons. They have key roles in nervous system …

Alternative splicing (AS) plays a major role in the generation of transcript diversity. In the
heart, roles have been described for some AS variants, but the global impact and regulation …

The postsynaptic density (PSD) is a collection of specialized proteins assembled beneath
the postsynaptic membrane of dendritic spines. The PSD proteome comprises~ 1000 …

Motivation High resolution annotation of gene functions is a central goal in functional
genomics. A single gene may produce multiple isoforms with different functions through …