Human brain development is under tight molecular genetic control and the recent advent of
single-cell genomics has revolutionized our ability to elucidate the diverse underlying cell …

Divergence of precursor messenger RNA (pre-mRNA) alternative splicing (AS) is
widespread in mammals, including primates, but the underlying mechanisms and functional …

Post-transcriptional mechanisms regulating cell surface synaptic organizing complexes that
control the properties of connections in brain circuits are poorly understood. Alternative …

Fragile X Syndrome is a neuro-developmental disorder caused by the silencing of the FMR1
gene, resulting in the loss of its protein product, FMRP. FMRP binds mRNA and represses …

Genetic mutations leading to the development of various diseases, such as cancer,
diabetes, and neurodegenerative disorders, can be attributed to multiple mechanisms and …

Background Special AT-rich sequence-binding protein 2 is essential for the development of
cerebral cortex and key molecular node for the establishment of proper neural circuitry and …

Considerable evidence from mouse models and human postmortem brain suggests loss of
Muscleblind-like protein 2 (MBNL2) function in brain is a major driver of CNS symptoms in …

ABSTRACT CHARGE syndrome is characterized by co-occurrence of multiple
malformations due to abnormal development of neural crest cells. Here, we review the …

Zebrafish is an attractive model to investigate regeneration of the nervous system. Despite
major progress in our understanding of the underlying processes, the transcriptomic …

Background Alternative splicing (AS) increases the diversity of transcriptome and could fine-
tune the function of genes, so that understanding the regulation of AS is vital. AS could be …