In the past two decades, mounting evidence has modified the classical view of the
cerebellum as a brain region specifically involved in the modulation of motor functions …

RNA binding proteins (RBPs) play a key role in cellular growth, homoeostasis and survival
and are tightly regulated. A deep understanding of their spatiotemporal regulation is needed …

Clusterin (CLU) is one of the risk genes most associated with late onset Alzheimer's disease
(AD), and several genetic variants in CLU are associated with AD risk. However, the …

Neuronal morphogenesis, integration into circuits, and remodeling of synaptic connections
occur in temporally and spatially defined steps. Accordingly, the expression of proteins and …

In patients with myotonic dystrophy type 1 (DM1), dysregulation of RNA-binding proteins like
MBNL and CELF1 leads to alternative splicing of exons and is thought to induce a return to …

DNA methylation in neurons is directly linked to neuronal genome regulation and
maturation. Unlike other tissues, vertebrate neurons accumulate high levels of atypical DNA …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high heritability,
however, understanding the complexity of the underlying genetic basis has proven to be a …

Gene expression during brain development or abnormal development is a biological
process that is highly dynamic in spatio and temporal. Previous studies have mainly focused …

The postsynaptic density (PSD) is a protein condensate composed of∼ 1,000 proteins
beneath the postsynaptic membrane of excitatory synapses. The number, shape, and …

Muscleblind-like splicing regulators (MBNLs) activate or repress the inclusion of alternative
splicing (AS) events, enabling the developmental transition of fetal mRNA splicing isoforms …