Background: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are 2 nonoperative
treatment options for knee osteoarthritis (OA) that are supposed to provide symptomatic …

Platelets produce platelet growth factors such as PDGF, IGF-1, EGF-, HGF, TGFβ, bFGF, and
VEGF, which are crucial in regulating all stages of the wound healing process. The source of …

Importance Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee
osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and …

Osteoarthritis (OA) is the most common joint disease in the world, with an age-associated
increase in both incidence and prevalence. Clinical and epidemiologic research is crucial to …

Background: Platelet-rich plasma (PRP) injections have been proposed as a new
conservative option for knee degeneration to provide symptomatic relief and delay surgical …

With an aging population, there is a proportional increase in the prevalence of intervertebral
disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and …

Objective To evaluate effectiveness, in terms of patient-reported outcome measures, of
platelet-rich plasma (PRP) injections for knee osteoarthritis compared to placebo and other …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Background Studies have shown that the combined application of hyaluronic acid (HA) and
platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of …

Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …