The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …

The ability to self-replicate is a fundamental feature of life, reflected at the cellular level by a
highly regulated process initiated in G1 phase via commitment to a round of DNA replication …

Deregulation of E2F1 activity and resistance to TGFβ are hallmarks of gastric cancer.
MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human …

E type cyclins (E1 and E2) are believed to drive cell entry into the S phase. It is widely
assumed that the two E type cyclins are critically required for proliferation of all cell types …

DNA damage is a common event and probably leads to mutation or deletion within
chromosomal DNA, which may cause cancer or premature aging. DNA damage induces …

Understanding the molecular and biochemical basis of cellular growth and division involves
the investigation of regulatory events that most often occur in a cell-cycle phase-dependent …

The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and
induces specific down-regulation of the cyclin-dependent kinase inhibitor p27 (p27 Kip1) …

Mammalian DNA replication is an elegantly choreographed process in which multiple
components are assembled at the origins to form the prereplication complex. Formation and …

E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell
cycle until the end of the S-phase. The activity of cyclin E is limiting for the passage of cells …

Cdc7 kinase, conserved from yeasts to human, plays important roles in DNA replication.
However, the mechanisms by which it stimulates initiation of DNA replication remain largely …