Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

T Hodgkinson, DC Kelly, CM Curtin… - Nature Reviews …, 2022 - nature.com
Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

Z Zhao, Y Li, M Wang, S Zhao, Z Zhao… - Journal of cellular and …, 2020 - Wiley Online Library
Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

H Yang, YI Wen, M Zhang, Q Liu, H Zhang, J Zhang… - Autophagy, 2020 - Taylor & Francis
ABSTRACT A switch from autophagy to apoptosis is implicated in chondrocytes during the
osteoarthritis (OA) progression with currently unknown mechanism (s). In this study we …

[HTML][HTML] Molecular signaling in temporomandibular joint osteoarthritis

K Lu, F Ma, D Yi, H Yu, L Tong, D Chen - Journal of orthopaedic translation, 2022 - Elsevier
Objective Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with
clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction …

[HTML][HTML] Initiation and progression of dental-stimulated temporomandibular joints osteoarthritis

Q Liu, H Yang, M Zhang, J Zhang, L Lu, S Yu… - Osteoarthritis and …, 2021 - Elsevier
Temporomandibular joint (TMJ), a site that is often impacted by osteoarthritis (OA), is
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …

Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis

Q Liu, R Wang, S Hou, F He, Y Ma, T Ye, S Yu… - Arthritis Research & …, 2022 - Springer
Backgrounds Abnormal cartilage calcification is one of the pathological changes of
temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that …

Joint diseases: from connexins to gap junctions

HJ Donahue, RW Qu, DC Genetos - Nature Reviews Rheumatology, 2018 - nature.com
Connexons form the basis of hemichannels and gap junctions. They are composed of six
tetraspan proteins called connexins. Connexons can function as individual hemichannels …

Biomaterial stiffness guides cross-talk between chondrocytes: implications for a novel cellular response in cartilage tissue engineering

L Cai, W Liu, Y Cui, Y Liu, W Du, L Zheng… - ACS Biomaterials …, 2020 - ACS Publications
The exquisite cartilage architecture maintains an orderly dynamic equilibrium as a result of
the interplay between chondrocyte functions and the unique extracellular matrix (ECM) …

[HTML][HTML] Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats

M Zhang, H Wang, J Zhang, H Zhang, H Yang… - Osteoarthritis and …, 2016 - Elsevier
Objective To investigate whether mechanical stress induces mineral deposits that contribute
to matrix degradation at the onset of osteoarthritis (OA) in temporomandibular joint (TMJ) …

Inhibition of Ihh reverses temporomandibular joint osteoarthritis via a PTH1R signaling dependent mechanism

H Yang, M Zhang, Q Liu, H Zhang, J Zhang… - International Journal of …, 2019 - mdpi.com
The temporomandibular joint (TMJ), which is biomechanically related to dental occlusion, is
often insulted by osteoarthritis (OA). This study was conducted to clarify the relationship …