Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis
Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint
H Yang, YI Wen, M Zhang, Q Liu, H Zhang, J Zhang… - Autophagy, 2020 - Taylor & Francis
ABSTRACT A switch from autophagy to apoptosis is implicated in chondrocytes during the
osteoarthritis (OA) progression with currently unknown mechanism (s). In this study we …
osteoarthritis (OA) progression with currently unknown mechanism (s). In this study we …
[HTML][HTML] Molecular signaling in temporomandibular joint osteoarthritis
Objective Temporomandibular joint (TMJ) osteoarthritis (OA) is a type of TMJ disorders with
clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction …
clinical symptoms of pain, movement limitation, cartilage degeneration and joint dysfunction …
[HTML][HTML] Initiation and progression of dental-stimulated temporomandibular joints osteoarthritis
Q Liu, H Yang, M Zhang, J Zhang, L Lu, S Yu… - Osteoarthritis and …, 2021 - Elsevier
Temporomandibular joint (TMJ), a site that is often impacted by osteoarthritis (OA), is
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …
Chondrocyte-derived exosomes promote cartilage calcification in temporomandibular joint osteoarthritis
Q Liu, R Wang, S Hou, F He, Y Ma, T Ye, S Yu… - Arthritis Research & …, 2022 - Springer
Backgrounds Abnormal cartilage calcification is one of the pathological changes of
temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that …
temporomandibular joint (TMJ) osteoarthritis (OA). Recent studies have reported that …
Joint diseases: from connexins to gap junctions
HJ Donahue, RW Qu, DC Genetos - Nature Reviews Rheumatology, 2018 - nature.com
Connexons form the basis of hemichannels and gap junctions. They are composed of six
tetraspan proteins called connexins. Connexons can function as individual hemichannels …
tetraspan proteins called connexins. Connexons can function as individual hemichannels …
Biomaterial stiffness guides cross-talk between chondrocytes: implications for a novel cellular response in cartilage tissue engineering
L Cai, W Liu, Y Cui, Y Liu, W Du, L Zheng… - ACS Biomaterials …, 2020 - ACS Publications
The exquisite cartilage architecture maintains an orderly dynamic equilibrium as a result of
the interplay between chondrocyte functions and the unique extracellular matrix (ECM) …
the interplay between chondrocyte functions and the unique extracellular matrix (ECM) …
[HTML][HTML] Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats
M Zhang, H Wang, J Zhang, H Zhang, H Yang… - Osteoarthritis and …, 2016 - Elsevier
Objective To investigate whether mechanical stress induces mineral deposits that contribute
to matrix degradation at the onset of osteoarthritis (OA) in temporomandibular joint (TMJ) …
to matrix degradation at the onset of osteoarthritis (OA) in temporomandibular joint (TMJ) …
Inhibition of Ihh reverses temporomandibular joint osteoarthritis via a PTH1R signaling dependent mechanism
H Yang, M Zhang, Q Liu, H Zhang, J Zhang… - International Journal of …, 2019 - mdpi.com
The temporomandibular joint (TMJ), which is biomechanically related to dental occlusion, is
often insulted by osteoarthritis (OA). This study was conducted to clarify the relationship …
often insulted by osteoarthritis (OA). This study was conducted to clarify the relationship …