Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The airway surface liquid (ASL) is a thin sheet of fluid that covers the luminal aspect of the
airway epithelium. The ASL is a site of several first-line host defenses, and its composition is …

Purpose Endotyping chronic rhinosinusitis with nasal polyps (CRSwNP) poses a challenge
for rhinologists nowadays. Phenotyping CRSwNP proved inappropriate as an approach to …

Introduction Cystic fibrosis (CF), a potentially fatal genetic disease, is caused by loss-of-
function mutations in the gene encoding for the CFTR chloride/bicarbonate channel …

Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing
loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic …

The fluid covering the surface of airway epithelia represents a first barrier against
pathogens. The chemical and physical properties of the airway surface fluid are controlled …

Several members of the SLC26A family of anion transporters associate with CFTR, forming
complexes in which CFTR and SLC26A functions are reciprocally regulated. These …

The pH of airway surface liquid (ASL) is a key factor that determines respiratory host
defense; ASL acidification impairs and alkalinization enhances key defense mechanisms …