Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to
contribute to reduced corticosteroid sensitivity of human airway epithelium. Here, we aimed …

The fluid covering the surface of airway epithelia represents a first barrier against
pathogens. The chemical and physical properties of the airway surface fluid are controlled …

Abstract Pendrin (SLC26A4) is a Cl−/anion exchanger expressed in the epithelium of
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …

Allergic fungal rhinosinusitis (AFRS) is a unique variety of chronic polypoid rhinosinusitis
usually in atopic individuals, characterized by presence of eosinophilic mucin and fungal …

The ability to regulate cell volume is crucial for normal physiology; equally the regulation of
extracellular fluid homeostasis is of great importance. Alteration of normal extracellular fluid …

The transport of chloride and bicarbonate across epithelia controls the pH and volume of the
intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion …

Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to
the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction …

Abstract The small GTPase RhoA and its downstream effectors are critical regulators in the
pathophysiological processes of asthma. The underlying mechanism, however, remains …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and cigarette
smoke is the main risk factor. Detecting its earliest stages and preventing a decline in lung …

Bicarbonate plays an important role in airway host defense, however, its transport
mechanisms remain uncertain. Here we examined the relative contributions of the anion …